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71.
Preparation and characterization of natural zeolite supported nano TiO2 photocatalysts by a modified electrostatic self‐assembly method 下载免费PDF全文
Cheng Wang Yan Li Huisheng Shi Jianfeng Huang 《Surface and interface analysis : SIA》2015,47(1):142-147
Natural zeolite supported nano TiO2 photocatalysts were prepared by a modified electrostatic self‐assembly (ESA) method. First, γ‐mercaptopropyltrimethoxysilane with sulfhydryl (―SH) functional groups was modified on the zeolite powders by using a ‘dry process’. Second, silane with ―SH functional groups was oxidized to sulfonate (―SO3H) groups by using a hydrogen peroxide/glacial acetic acid mixed solution, and the surface of ―SO3H silane–zeolite was electronegative charged due to the ionization of ―SO3H. Third, the hydrolytic titanium polycation from TiCl4 solution assembled onto the electronegative charged zeolite under electrostatic attraction in the reaction solutions. Finally, zeolite supported nano TiO2 photocatalysts can be obtained after the above compounds calcined at certain temperature. The samples were characterized by X‐ray diffraction (XRD), Brunauer–Emmett–Teller (BET) surface areas, Fourier transform infrared spectroscopy (FT‐IR), X‐ray photoelectron spectroscopy (XPS) and X‐ray fluorescence (XRF). The photocatalytic activities of the samples were evaluated by the degradation of methyl orange in aqueous solution. The results showed that ESA method effectively improved the composite efficiency of zeolite with TiO2. The photocatalysts prepared by ESA method exhibited higher photocatalytic and recycling activities than that of traditional method. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
72.
Protein kinase C (PKC) plays a key role in neurotransmission in the central nervous system, and targeting PKC domain is considered as a strategy to modulate the anaesthetic effects. In this study, we described a synthetic pipeline to perform high-throughput virtual screening against a large library of 3D structural natural products released recently in order to discover those potential PKC modulators. A total of 100 natural products with top scores were raised, from which 12 promising candidates were tested to determine their inhibitory potencies against PKC. As might be expected, the promiscuous kinase inhibitor staurosporine showed a high PKC inhibitory activity (IC50 = 64 nM), and other two tested compounds, i.e. fisetin and tetrahydropapaverine, were also highly potent with their activities at nanomolar level (IC50 = 370 and 190, respectively). 相似文献
73.
《Comptes Rendus Chimie》2015,18(10):1134-1142
Pharmaceuticals, personal care products and endocrine disruptors demonstrate huge potential to cause adverse ecological health effects at very low concentration in aquatic environment. There is a need to improve current purification technologies used in sewage and drinking-water treatment plants. This article aims at providing new insights into the recent development of natural and modified clay-based sorbents for the removal of aqueous contaminants such as pharmaceuticals and personal care products. The removal of six widely used pharmaceuticals: ibuprofen, diclofenac, ketoprofen, carbamazepine, as well as endocrine disrupting chemicals – bisphenol A and a bactericidal agent, triclosan – was examined by sorption onto eight adsorbents. Sorption was performed using natural and modified clay minerals – montmorillonite (Mt), vermiculite (VER), bentonite (B), kaolinite (K), commercial acid activated montmorillonites K10 and K30, and two carbonaceous-mineral nanocomposites, MtG5%T, BAlG3%C. This study showed that among the tested natural clays, vermiculite is the most promising sorbent for the removal of pharmaceuticals in purification processes. Among the modified clay minerals, the best results were achieved for carbonaceous bentonite and two acid activated montmorillonites K10 and K30. However, the removal of acidic pharmaceuticals on montomorillonite K10 and carbonaceous bentonite was strongly dependent on the pH value. In the case of vermiculite and acid-modified montmorillonite K30, the sorption of the selected compounds was not significantly affected by pH, which is crucial in wastewater treatment. The sorption constant divided by the specific surface area (Kd/A) is proposed to assess whether the surface area or chemical properties of the materials control the sorption process. Kd/A values were relatively high in the case of vermiculite, so it should be noticed that individual and specific surface properties of vermiculite were of crucial importance for sorption. 相似文献
74.
Krishnan Ravikumar Balasubramanian Sridhar Jagadeesh Babu Nanubolu Tamilselvan Rajasekaran Basi Venkata Subba Reddy 《Acta Crystallographica. Section C, Structural Chemistry》2015,71(4):322-329
Four structures of oxoindolyl α‐hydroxy‐β‐amino acid derivatives, namely, methyl 2‐{3‐[(tert‐butoxycarbonyl)amino]‐1‐methyl‐2‐oxoindolin‐3‐yl}‐2‐methoxy‐2‐phenylacetate, C24H28N2O6, (I), methyl 2‐{3‐[(tert‐butoxycarbonyl)amino]‐1‐methyl‐2‐oxoindolin‐3‐yl}‐2‐ethoxy‐2‐phenylacetate, C25H30N2O6, (II), methyl 2‐{3‐[(tert‐butoxycarbonyl)amino]‐1‐methyl‐2‐oxoindolin‐3‐yl}‐2‐[(4‐methoxybenzyl)oxy]‐2‐phenylacetate, C31H34N2O7, (III), and methyl 2‐[(anthracen‐9‐yl)methoxy]‐2‐{3‐[(tert‐butoxycarbonyl)amino]‐1‐methyl‐2‐oxoindolin‐3‐yl}‐2‐phenylacetate, C38H36N2O6, (IV), have been determined. The diastereoselectivity of the chemical reaction involving α‐diazoesters and isatin imines in the presence of benzyl alcohol is confirmed through the relative configuration of the two stereogenic centres. In esters (I) and (III), the amide group adopts an anti conformation, whereas the conformation is syn in esters (II) and (IV). Nevertheless, the amide group forms intramolecular N—H...O hydrogen bonds with the ester and ether O atoms in all four structures. The ether‐linked substituents are in the extended conformation in all four structures. Ester (II) is dominated by intermolecular N—H...O hydrogen‐bond interactions. In contrast, the remaining three structures are sustained by C—H...O hydrogen‐bond interactions. 相似文献
75.
狄尔斯-阿尔德(Diels-Alder)可以构建结构丰富的有机化合物,被认为是现代有机化学中的基石反应之一。自1928年被发现以来,Diels-Alder (D-A)反应得到了深入发展,这主要是由于该反应能够产生六元环结构,可以一步反应得到具有四个立体中心的产物,从而大大增加分子的复杂性。这种特殊的转化已广泛应用于复杂天然产物的合成、药物化学以及材料科学等领域。近十年,大量天然生物酶(如SpnF、MaDA等)被发现可用于体外单独催化D-A反应,同时,大量的非酶催化剂(如路易斯酸、过渡金属与配体复合物等)也被应用于催化D-A反应。本文主要从D-A反应催化剂的类型分类,对近年来天然酶、酸、过渡金属、电催化等参与的D-A反应进行简要概述,同时对催化剂所存在的问题和局限性进行总结,并对今后发展做了展望。 相似文献
76.
Li Yang Li-yuan Xie Xuan Chen Xiao-hong Bai Shuang Hu 《Journal of separation science》2022,45(13):2252-2261
A novel solvent terminated microextraction method based on a natural deep eutectic solvent (L-menthol and lactic acid at a molar ratio of 1:2) coupled with high-performance liquid chromatography was proposed, which was utilized for the separation and enrichment of bisdemethoxycurcumin, demethoxycurcumin and curcumin in Curcumae Longae Rhizoma and turmeric tea. The effects of independent parameters on extraction efficiency were optimized by single-factor analysis. Subsequently, four predominated parameters affecting the extraction procedure, including extractant volume, salt concentration, demulsifier consumption, and demulsification time, were further evaluated by a central composite design. Under the optimized conditions, the linear ranges of calibration curves were 0.005–0.5 μg/mL for bisdemethoxycurcumin, 0.004–0.4 μg/mL for demethoxycurcumin, and 0.0045–0.45 μg/mL for curcumin, respectively. In addition, the developed method provided low detection limits (0.1–0.4 ng/mL) and high enrichment factors (279–350). Its intra-day and inter-day precision were carried out by relative standard deviation ranging from 2.2 to 9.2%. Finally, the applicability of this method was assessed by the analysis of Curcumae Longae Rhizoma and turmeric tea samples. The results showed that these samples were detected successfully and the spiked recoveries over the range of 85.3-108.9% with relative standard deviations of 1.6-8.9% were attained, indicating its high relative recoveries with good precision in real sample analysis. 相似文献
77.
Julian Hofmann Dr. Tiziana Ginex Dr. Alba Espargaró Matthias Scheiner Sandra Gunesch Marc Aragó Prof. Dr. Christian Stigloher Prof. Dr. Raimon Sabaté Prof. Dr. F. Javier Luque Prof. Dr. Michael Decker 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(19):6015-6027
Many (poly-)phenolic natural products, for example, curcumin and taxifolin, have been studied for their activity against specific hallmarks of neurodegeneration, such as amyloid-β 42 (Aβ42) aggregation and neuroinflammation. Due to their drawbacks, arising from poor pharmacokinetics, rapid metabolism, and even instability in aqueous medium, the biological activity of azobenzene compounds carrying a pharmacophoric catechol group, which have been designed as bioisoteres of curcumin has been examined. Molecular simulations reveal the ability of these compounds to form a hydrophobic cluster with Aβ42, which adopts different folds, affecting the propensity to populate fibril-like conformations. Furthermore, the curcumin bioisosteres exceeded the parent compound in activity against Aβ42 aggregation inhibition, glutamate-induced intracellular oxidative stress in HT22 cells, and neuroinflammation in microglial BV-2 cells. The most active compound prevented apoptosis of HT22 cells at a concentration of 2.5 μm (83 % cell survival), whereas curcumin only showed very low protection at 10 μm (21 % cell survival). 相似文献
78.
Dr. Elisa Bonandi Dr. Mattia Mori Dr. Paola Infante Dr. Irene Basili Prof. Dr. Lucia Di Marcotullio Dr. Andrea Calcaterra Dr. Federica Catti Prof. Dr. Bruno Botta Prof. Dr. Daniele Passarella 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(32):8350-8357
Withanolides constitute a well-known family of plant-based alkaloids characterised by widespread biological properties, including the ability of interfering with Hedgehog (Hh) signalling pathway. Following our interest in natural products and in anticancer compounds, we report here the synthesis of a new class of Hh signalling pathway inhibitors, inspired by withaferin A, the first isolated member of withanolides. The decoration of our scaffolds was rationally supported by in silico studies, while functional evaluation revealed promising candidates, confirming once again the importance of natural products as inspiration source for the discovery of novel bioactive compounds. A stereoselective approach, based on Brown chemistry, allowed the obtainment and the functional evaluation of the enantiopure hit compounds. 相似文献
79.
Veselin Nasufović Dr. Florian Küllmer Johanna Bößneck Dr. Hans-Martin Dahse Dr. Helmar Görls Dr. Peter Bellstedt Dr. Pierre Stallforth Prof. Dr. Hans-Dieter Arndt 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(45):11633-11642
The first total synthesis of the actin-stabilizing marine natural product geodiamolide H was achieved. Solid-phase based peptide assembly paired with scalable stereoselective syntheses of polyketide building blocks and an optimized esterification set the stage for investigating the key ring-closing metathesis. Geodiamolide H and synthetic analogues were characterized for their toxicity and for antiproliferative effects in cellulo, by characterising actin polymerization induction in vitro, and by docking on the F-actin target and property computation in silico, for a better understanding of structure-activity relationships (SAR). A non-natural analogue of geodiamolide H was discovered to be most potent in the series, suggesting significant potential for tool compound design. 相似文献
80.
色谱柱分类数据库用于指导天然药物化学对照品色谱纯度测定时色谱柱理性选择 总被引:2,自引:0,他引:2
由于中药化学对照品多数来源于动植物药材,很容易混有结构类似物,故有机杂质测定是可能影响其化学对照品赋值准确性的关键风险因素。中药化学对照品的有机杂质测定通常采用药典收载或文献报道的高效液相色谱法,这些方法通常仅规定“以十八烷基硅烷键合硅胶为填充剂”,无适宜色谱柱的品牌信息,或者实验室无文献所用的色谱柱品牌,而目前市场上已有800多种品牌的C18柱,生产工艺的不同导致不同品牌C18柱的选择性有差异,甚至差异显著。这很容易出现由于色谱柱选择不适宜而导致测定结果不准确的风险。该文采用国外色谱柱分类数据库指导对照品纯度考察时色谱柱的理性选择,尽可能减少色谱柱盲选可能导致的纯度结果不准确的风险。首先,用数据库挑选2根选择性差异显著的色谱柱(选择性因子F≥6)进行平行实验,以尽可能反映采用不同品牌色谱柱可能出现的分离效果差异。如果这2根色谱柱的分离效果及纯度测定结果无显著性差异,则可以交叉验证该对照品纯度测定的准确性。否则需要从数据库中选择另外1根与之前试验中分离效果更好、选择性相似的色谱柱进行纯度结果验证。在N-反式-p-对香豆酰基酪胺和表儿茶素没食子酸酯首批对照品的纯度考察中,使用了上述策略并验证了其有效性和科学性,计划推广应用至更多的中药化学对照品,特别当其可能含碱性或弱酸性化合物时,更应该尝试采用本文推荐的色谱柱选择策略交叉验证其纯度测定结果的准确性。 相似文献